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IP International Journal of Medical Microbiology and Tropical Diseases

Etiological divergence and antimicrobial susceptibility pattern among culture proven cases of neonatal sepsis from a tertiary care teaching institute in a konkan region of Maharashtra

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Research Article

Author Details : Yogendra Pandurang Shelke, Prasanna Nakate*, Snehal Patil, Suvarna Patil, Tupat Smita Laxman

Volume : 5, Issue : 4, Year : 2019

Article Page : 230-237

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Introduction: Neonatal mortality is one of the major obstacle to achieve present days health goals of world
health organization & neonatal sepsis is important preventable causes behind neonatal mortality all over
the world. Analysis of etiology of neonatal sepsis and antimicrobial susceptibility pattern among isolates
helps in implementation of antimicrobial policy in NICU for rational empirical antibiotics.
Aim and Objectives: This study was carried out to analyze etiology, the change in trends in bacteriological
agents of neonatal sepsis & also studying antimicrobial susceptibility pattern in these different isolates
during study period.
Materials and Methods: This is a retrospective observational study. In this study all the records of blood
culture samples taken from suspected neonatal sepsis cases in NICU & which are received & processed in
Microbiology department are analyzed, during January 2017 to August 2019.
Results: Total 400 blood culture reports were analyzed from 400 suspected neonatal sepsis cases, out of
that 98 were pure growth indicating 24.50% culture positivity. In these cases of neonatal sepsis 57 were
male & 41 were female. These newborn with sepsis had risk factors like preterm neonates (55.10%) low
birth weight (53.06%) & Birth asphyxia (31.63%). Though there was Year wise variation observed in
etiological agents of neonatal sepsis Overall 77(78.57%) isolates were gram negative organism & The most
common etiological agent of neonatal sepsis was Pantoea Species (25 isolates) followed by Klebsiella
species (24 isolates). It was observed that against antimicrobial agent’s like ceftazidime, ceftazidime
clavunic acid, cefoperazone, piperacillin tazobactum, ampicillin & cefoperazone sulbactum gram negative
isolates showed marked resistance. While gram positive isolates showed resistance towards penicillin,
cefoxitin, azithromycin & calirithromycin. High Mortality 25.51% was seen in culture proven cases of
neonatal sepsis.
Conclusion: We observed year wise variations in etiology of neonatal sepsis during study duration which
point out need of continuous monitoring and surveillance to prevent morbidity and mortality of neonatal
sepsis in konkan region.

Keywords: Culture Proven, Neonatal sepsis, Etiological divergence, Antimicrobial susceptibility, Konkan region.

Doi : 10.18231/j.ijmmtd.2019.053

How to cite : Shelke Y P, Nakate P, Patil S, Patil S, Laxman T S, Etiological divergence and antimicrobial susceptibility pattern among culture proven cases of neonatal sepsis from a tertiary care teaching institute in a konkan region of Maharashtra. IP Int J Med Microbiol Trop Dis 2019;5(4):230-237

Copyright © 2019 by author(s) and IP Int J Med Microbiol Trop Dis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (