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IP Indian Journal of Neurosciences

Neuro-Anatomical Study of a Rare Brain Malformation: Lissencephaly, A Report of Eleven Patients

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Author Details : Kataria Sushma K, Gurjar Anoop S, Parakh Manish, Gurjar Manisha, Parakh Poonam, Sharma Rameshwar P

Volume : 2, Issue : 1, Year : 2016

Article Page : 1-5

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Background and Objectives: Clinical data and magnetic resonance imaging (MRI) / Computerised Tomography (CT) scans of patients with lissencephaly were reviewed.  The clinico-anatomic profile and type of lissencephaly in patients attending the Paediatric Neurology Clinic in Western Rajasthan was determined. The major comorbid conditions, maternal and fetal factors associated with lissencephaly were also studied.
Methods: Patients with radiologically proven lissencephaly were included in the study. A detailed epidemiologic profile, clinical history, neurologic examination and neuro-imaging details (CT/MRI) were recorded.  The data collected was analyzed.
Results and Interpretation: The prevalence of lissencephaly amongst the patients attending the clinic was 0.49%.  All patients had anatomical features compatible with impaired neuronal migration. Seizure was the most common comorbid (90.9%) condition associated with lissencephaly.
Conclusion: MRI and appropriate genetic studies as feasible should be done to aid in accurate clinco-anatomic and genetic diagnosis in all patients suspected of having a congenital Central Nervous System (CNS) malformation such as lissencephaly.

Key words: CNS Malformations, Heterotopias, Lissencephaly, Neuronal Migration, Seizures


How to cite : Kataria Sushma K, Gurjar Anoop S, Manish P, Manisha G, Poonam P, Sharma Rameshwar P, Neuro-Anatomical Study of a Rare Brain Malformation: Lissencephaly, A Report of Eleven Patients. IP Indian J Neurosci 2016;2(1):1-5

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