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Indian Journal of Obstetrics and Gynecology Research


Intravenous Labetalol in management of Hypertensive Emergencies in Pregnancy


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Author Details : Omkara Murthy K, Dhananjaya BS, Jamuna R, Chaitra R

Volume : 3, Issue : 4, Year : 2016

Article Page : 352-355


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Abstract

Background: To study the effect of IV labetalol   in hypertensive emergencies in pregnancy and their effects on maternal and Perinatal outcome. Pregnant women with blood pressure >160/110 mmHg were subjected to the trial. Patients were randomized to receive intravenous labetalol injection (in an escalating dose regimen of 20, 40, 80, 80 and 80 mg) every 15 minutes until the target blood pressure of <150/100 mmHg was achieved. Addition of nifedipine treatment was done if the initial treatment regimen was unsuccessful. Primary and secondary outcomes like the time interval and number of doses required to achieve a blood pressure of ≤150/100 mmHg and adverse effects of the antihypertensive agents were reported.
IV Labetalol is effective in sustaining therapeutic level.
Objective: To study the efficacy of IV Labetalol in management of hypertensive emergencies in pregnancy and adverse effects of labetalol.
Materials and methods: A prospective observational study of 60 cases with hypertension in pregnancy, treated with Labetalol, was conducted over a period of one and half years.
Results: The effective control of blood pressure with the use of Labetalol in the dosage used, was observed in cases of moderate to severe pregnancy induced hypertension.
Conclusion: Intravenous labetalol is an effective and safe drug in the management of hypertension in pregnancy.

Keywords:
Hypertension, Pregnancy, Labetalol

How to cite : Omkara Murthy K, Dhananjaya Bs, Jamuna R, Chaitra R, Intravenous Labetalol in management of Hypertensive Emergencies in Pregnancy. Indian J Obstet Gynecol Res 2016;3(4):352-355

Copyright © 2016 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)