COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-2746

Online ISSN:-2394-2754

CODEN : IJOGCS

Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 692

Emailed: 0

PDF Downloaded: 299

Indian Journal of Obstetrics and Gynecology Research


Comparison of single loading dose magnesium sulphate regimen with low dose magnesium sulphate regimen in the treatment of eclampsia


Full Text PDF Share on Facebook Share on Twitter


Author Details : Sunitha HB, Sonam Parikh, Manjushree R Waikar, Vinayak Panchgar, Akshaya N. Shetti

Volume : 4, Issue : 4, Year : 2017

Article Page : 338-342


Suggest article by email


Abstract

Introduction: Eclampsia contributes to maternal mortality in developing, underdeveloped world. Various drugs have been tried to treat eclampsia. Magnesium sulphate has become the drug of choice due to various advantages and is associated with adverse outcome for both mother and fetus if not used correctly. This study was undertaken to know safety, efficacy of reduced doses of Magnesium sulphate as compared to standard dose.
Materials and Method: After obtaining institution ethical clearance and written informed consent this study was conducted on 60 subjects for 2 years. Patients diagnosed as eclampsia and presenting with generalized tonic clonic seizure during antenatal, intrapartum, postnatal were included. Group A received single loading dose of magnesium sulphate (4gm (20%) I V over 3-5 min followed by 10gm (50%) deep i.m. (5gm in each buttock)). Group B patients received low dose magnesium sulphate (4gm (20%) i.v. over 3-5 min followed by 6gm (50%) deep i.m. (3 gm in each buttock) and maintenance dose of 3 gm i.m., every 4 hourly in alternate buttock) which was continued 24 hours after last convulsion or delivery whichever is later. Mode of delivery, recurrence of convulsion, maternal and fetal morbidity and mortality were studied.
Results: Maternal and foetal outcome was comparable in both the groups. There was no significant difference with regards to recurrence of convulsions. There was no statistically significant increase in incidence of caesarian section in group B compared to group A (p>0.05).
Conclusion: Single dose regime controls the eclamptic convulsions with good maternal and neonatal outcome.

Keywords:
Eclampsia, Low dose, Magnesium sulphate

How to cite : Sunitha Hb, Parikh S, Waikar M R, Panchgar V, Shetti A N, Comparison of single loading dose magnesium sulphate regimen with low dose magnesium sulphate regimen in the treatment of eclampsia. Indian J Obstet Gynecol Res 2017;4(4):338-342

Copyright © 2017 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)