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Indian Journal of Obstetrics and Gynecology Research

A retrospective study of effect of thyroid disorders on obstetric and perinatal outcomes: A hospital based study

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Author Details : Rohini N. S, Ravishankar S. N, Madhuvan H. S, Sudha Patil, Rakshith N. R

Volume : 5, Issue : 2, Year : 2018

Article Page : 247-252

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Aims and Objectives: The study was undertaken in pregnant women to understand and analyze the obstetric and fetal outcomes of thyroid disorders.
Materials and Methods: TSH estimation was used as universal screening in their first visit to our hospital. Those patients with abnormal TSH values, i.e. above 2.5mIU/ml in first trimester and above 3mIU/ml in second and third trimesters were evaluated for freeT3, freeT4 and TPO Abs. They were treated accordingly and dosage adjustments made and the tests repeated once in 4-6 weeks. They were followed throughout pregnancy and delivery.
Results: Total no of pregnant women screened were 860, of which 130 had abnormal thyroid functions, thereby the prevalence of thyroid dis­orders being 15.11%. Of the 130 patients with thyroid disorders, 126 were hypothyroid and 4 were hyperthyroid. Among the 126 hypothy­roid cases, 48 were known cases and 78 were new cases. The total cases of subclinical hypothyroidism were 91, prevalence being 10.58% and overt cases were 35, prevalence being 4.06%; 4 cases were overt hyperthyroid, prevalence being 0.4%. 60.3% of subclinical hypothy­roidism were TPO positive and 39.6% of overt hypothyroidism were TPO positive (p value-<0.05). Out of 130 abnormal thyroid function patients, 98 patients delivered in our hospital. There were 16 abor­tions, 14 spontaneous and 2 terminations of pregnancies; 6 patients were lost for follow up, 7 patients have delivered outside and 1 patient lost follow up.
Conclusions: The prevalence of thyroid disorders during pregnancy was significantly more in our study, hypothyroidism being the commonest.
Significant numbers of cases were newly diagnosed on universal screening. The commonest disorder was subclinical hypothyroidism. Adverse maternal and fetal outcomes were almost similar in both subclinical and overt hypothyroidism. The common adverse outcomes noted were abortions, pre-eclampsia, gestational diabetes mellitus, preterm births and increased rates of caesarean sections. The adverse outcomes were significantly more in autoimmune antibody positive patients.

Keywords: Sub-clinical hypothyroidism, Overt hypothyroidism, Thyro ­peroxidase antibody (TPO Abs), Hyperthyroidism, preterm abortions, IUGR, Eclampsia.

Doi : 10.18231/2394-2754.2018.0055

How to cite : Rohini N. S, Ravishankar S. N, Madhuvan H. S, Patil S, Rakshith N. R, A retrospective study of effect of thyroid disorders on obstetric and perinatal outcomes: A hospital based study. Indian J Obstet Gynecol Res 2018;5(2):247-252

Copyright © 2018 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (