COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-2746

Online ISSN:-2394-2754

CODEN : IJOGCS

Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 701

Emailed: 0

PDF Downloaded: 328

Indian Journal of Obstetrics and Gynecology Research


Comparison of effectiveness of ormeloxifene with norethisterone in perimenopausal DUB treatment


Full Text PDF Share on Facebook Share on Twitter


Research Article

Author Details : Surabhi HD, Chandra Mouli A*

Volume : 6, Issue : 2, Year : 2019

Article Page : 137-140


Suggest article by email


Abstract

Introduction: Dysfunctional Uterine Bleeding, is Abnormal uterine bleeding in the absence of organic, systemic, iatrogenic cause.1 Norethisterone acetate is commoly used progesterone derivative for management.2 Ormeloxifene, a selective estrogen receptor modulator is an another alternate treatment for DUB.3 Study was conducted at MVJ Medical College Bangalore. 
Objective: to compare treatment efficacy and usefulnes of Ormeloxifene and oral progesterone in DUB treatment.
Materials and Methods: Total of 60 perimenopausal women with DUB were enrolled in our prospective study. They were randomly assigned to group A and group B.
Group A: 30 women with DUB were treated with 60mg Ormeloxifene two times a week for 3 months, 60mg weekly once for next 3 months.
Group B: Norethisterone 5 mg two times a day for 21 days for 6 cycles.
Results: In our study even though Norethistrone group showed significant reduction in blood loss and also increase in haemoglobin level, these results were significantly less when compared with Ormeloxifene group.
In addition Ormeloxifene group showed significant reduction in endometrial thickness, which was not significantly reduced in Norethisterone group. As a result of significant reduction of endometrial thickness among the women treated with Ormeloxifene.

Conclusion: In the study Ormeloxifene was found to be effective than Norethisterone in reducing blood loss, improving Haemoglobin level and reducing endometrial thickness for treating DUB patients. Also compliance of the patients was good because drug was well tolerated, convenient dosage schedule for treatment of DUB.

Keywords: Ormeloxifene, Norethisterone, Haemoglobin, Endometrial thickness, PBAC.

Doi : 10.18231/j.ijogr.2019.032

How to cite : Surabhi Hd, Chandra Mouli A, Comparison of effectiveness of ormeloxifene with norethisterone in perimenopausal DUB treatment. Indian J Obstet Gynecol Res 2019;6(2):137-140

Copyright © 2019 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)