COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 324

Article download: 177

Indian Journal of Obstetrics and Gynecology Research

Assessment of oxidative stress markers and level of antioxidant in preeclampsia

Full Text PDF Share on Facebook Share on Twitter

Research Article

Author Details : Mona Omar*, Hesham M Borg

Volume : 6, Issue : 3, Year : 2019

Article Page : 268-275

Suggest article by email


Introduction: In pre-eclampsia the pathophysiology is still under investigation. Lipid peroxidation is
important for the normal endothelial cell function. The antioxidant like Vitamin E and vitamin C play a
role in preventing preeclampsia.
Materials and Methods: We compare between serum malondialdehyde (MDA) level, a product of
lipid peroxide and the antioxidant (vitamin C and E) in pregnant women with or without preeclampsia.
Patient are divided to two group; Group 1 (n=50): pregnant women between 28 and 40 weeks’ gestation
with preeclampsia and Group 2(n=50): the control group includes pregnant women without hypertension
episode during their pregnancy.
Result: Serum MDA levels were raised in women with preeclampsia compared with normal pregnancy
(P < 0> blood pressure in preeclamptic and normal pregnancies (rs = 0.693, p<0 rs =0.467,> respectively. Vitamin C, E level show s highly significant decrease in Pre-eclamptic women than normal
one (p<0> pressure and diastolic blood pressure (P<0> between vitamin E level (mg/dl) and both systolic blood pressure and diastolic blood pressure (P <0> (P <0> Conclusion: These results provide further evidence that excessive lipid peroxidation level and decreases
in vitamin E and C levels (which are responsible from antioxidant activity) may contribute to the
pathophysiology and pathogenesis of preeclampsia.

Keywords: Preeclampsia, Lipid peroxidation, Vitamin E and vitamin C.

Doi : 10.18231/j.ijogr.2019.062

How to cite : Omar M, Borg H M, Assessment of oxidative stress markers and level of antioxidant in preeclampsia. Indian J Obstet Gynecol Res 2019;6(3):268-275

Copyright © 2019 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (