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International Journal of Pharmaceutical Chemistry and Analysis


Validated spectrophotometric method for simultaneous estimation of rosuvastatin calcium and aspirin in tablet dosage forms


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Author Details : Gandla Kumaraswamy, Repeudi Lalitha, K. Vijayaprakash

Volume : 3, Issue : 2, Year : 2016

Article Page : 90-98


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Abstract

The present work was aimed at method development and validation for simultaneous estimation of Rosuvastatin Calcium and Aspirin by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method 0.1N NaoH as solvent and λmax of Rosuvastatin Calcium and Aspirin were found to be 232 nm and 222 nm respectively. Concentration ranges were found to be 4-20µg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Rosuvastatin Calcium and Aspirin respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95-105% for Rosuvastatin Calcium and Aspirin. LOD and LOQ ranges were found to be 0.177 and 0.539µg/mL and 0.298 and 0.903µg/mL for Rosuvastatin Calcium and Aspirin respectively. This method was validated using ICH guidelines.

Key words: Aspirin, Rosuvastatin, UV-Spectrophotometric method, Simultaneous equation, Validation

How to cite : Kumaraswamy G, Lalitha R, Vijayaprakash K, Validated spectrophotometric method for simultaneous estimation of rosuvastatin calcium and aspirin in tablet dosage forms. Int J Pharm Chem Anal 2016;3(2):90-98

Copyright © 2016 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)