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International Journal of Pharmaceutical Chemistry and Analysis


Synthesis, characterization and evaluation of some benzothiazole derivatives bearing oxindole moiety as potential anticancer agents


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Author Details : Kakadiya Dipesh, Malleshappa N. Noolvi

Volume : 3, Issue : 3, Year : 2016

Article Page : 143-149


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Abstract

This study was aimed at investigating the antitumor activity of novel 5-substituted 2-oxindole derivatives. A series of oxindole derivatives of N-(1,3,4-thiadiazol-2-yl)benzo[d]thiazol-2-amine were prepared and confirmed by 1H NMR, mass and IR data. These compounds were evaluated for their anticancer activity at National Cancer Institute (NCI), USA by single High dose (10-5 M) in full NCI 60 cell panel. Primary in vitro one dose anticancer assay was performed in full NCI 60 cell panel representing leukaemia, melanoma and cancers of lung, colon, brain, breast, ovary, kidney and prostate. Among them compound 1[D] has showed moderate anticancer activity while compound 3[A-2] has showed significant anticancer activity with overall mean growth percent 38.25. These findings prompt us to further explore the oxindole structure as leading scaffold to design new molecules with potent antitumor activity.

Keywords:
2-Oxindole, 1,3,4-thiadiazole, Benzothiazole, Anticancer, NCI

 

How to cite : Dipesh K, Noolvi M N, Synthesis, characterization and evaluation of some benzothiazole derivatives bearing oxindole moiety as potential anticancer agents. Int J Pharm Chem Anal 2016;3(3):143-149

Copyright © 2016 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)