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International Journal of Pharmaceutical Chemistry and Analysis

Similarity Analysis studies on (Sulfonyl) Benzene Derivatives as Anti HIV Agents

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Author Details : Shweta Sharma, Smrita Singh, Mymoona Akhter, Sarvesh Paliwal

Volume : 3, Issue : 3, Year : 2016

Article Page : 174-182

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Introduction: The present investigation was undertaken to understand the overlaying problems of mutation in HIV virus leading to failure to combat AIDS.
Materials and Methods: In present study Multiple Linear Regression (MLR) analysis was carried on a series of 71(sulfonyl) benzene analogs reported as viral nucleocapsid protein zinc finger modulators for HIV.
Results: The MLR model obtained using carbo method (N*N) similarity showing good predictive ability, r2 (training) = 0.655, r2(test) = 0.605.
Conclusion: The results indicated that Refractivity Similarity (polarizability and volume) and Shape Similarity are important parameters in predicting the activity of viral nucleocapsid protein zinc finger inhibitors.

Refractivity Similarity, Shape Simliarity, Carbo, MLR, Viral Nucleocapsid Protein Zinc Finger, HIV

How to cite : Sharma S, Singh S, Akhter M, Paliwal S, Similarity Analysis studies on (Sulfonyl) Benzene Derivatives as Anti HIV Agents. Int J Pharm Chem Anal 2016;3(3):174-182

Copyright © 2016 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (