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International Journal of Pharmaceutical Chemistry and Analysis


Substituted benzimidazoles: A novel class of anti-tubercular agents


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Research Article

Author Details : Senthilraja Manivannan*

Volume : 6, Issue : 1, Year : 2019

Article Page : 10-13


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Abstract

Reaction of O-phenylenediamine with phthalic anhydride gives 2H-benzimidazole -1-yl-3, 8 - benzpyrolidine - 2-one (I) This on condensation with anthranilic acid and 4-aminoacetophenone gives II. II on reaction with different aldehydes in presence of sodium hydroxide and ethanol stirred at room temperature for 24 h gives N-[4-(3-Aryl-acryloyl)–phenyl]–2-(1H– benzimidazol–2–yl)–benzamide (III-X). All the compounds have been characterized by elemental analysis, IR and NMR and Mass spectral analysis. All the compounds have been evaluated for their anti-tubercular activity against different stain of mycobacterium species.

Keywords: Benzimidazole, O-phenylenediamine, Tuberculastatics, Antimicrobials, Aminobenzaldehyde.

Doi : 10.18231/j.ijpca.2019.003

How to cite : Manivannan S, Substituted benzimidazoles: A novel class of anti-tubercular agents. Int J Pharm Chem Anal 2019;6(1):10-13

Copyright © 2019 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)