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International Journal of Pharmaceutical Chemistry and Analysis


Microwave assisted synthesis and pharmacological evaluation of few substituted 4-thiazolidinone derivatives


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Research Article

Author Details : Dinesh D. Rishipathak*, Poonam S.Wajpeyi, Sonal P. Tathe, Pavan B. Udavant

Volume : 6, Issue : 2, Year : 2019

Article Page : 44-48


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Abstract

In present investigation the synthesis of few 2-(substituted phenyl-3-(5-substituted phenyl-4H-1, 2, 4-triazole-3-yl)-thiazolidine-4-ones and 3-(5-(4-substituted phenyl)-1, 3, 4-thiadiazole-2-yl)-2-phenylthiazolidine-4-ones is reported with the aim of achieving enhanced anticonvulsant effect. Two schemes were designed viz. first scheme for clubbed triazole-thiazolidinone derivatives and second scheme for clubbed thiadiazole-thiazolidinone derivatives. The compounds were characterized on the basis of IR, 1H-NMR and Mass analyses. Acute toxicity study was done to determine the LD50 of the compounds. Some of the compounds were evaluated for their anticonvulsant activity using PTZ induced convulsions method. The compounds DCThizd-N and NMThizd-N showed highest percentage of protection (80%) at the dose of 30mg/kg among the evaluated compounds compared to control.

Keywords: 4-Thiazolidinone, Triazole, Thiadiazole, Anticonvulsant activity.

Doi : 10.18231/j.ijpca.2019.008

How to cite : Rishipathak D D, S.wajpeyi P, Tathe S P, Udavant P B, Microwave assisted synthesis and pharmacological evaluation of few substituted 4-thiazolidinone derivatives. Int J Pharm Chem Anal 2019;6(2):44-48

Copyright © 2019 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)