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International Journal of Pharmaceutical Chemistry and Analysis


Synthesis of some nuclear substitution derivatives of 4-acetyl pyridine


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Author Details : Joohee Pradhan, Anju Goyal

Volume : 2, Issue : 3, Year : 2015

Article Page : 113-119


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Abstract

Five nuclear substitution derivatives of 4- acetyl pyridine (2a to 6a) were prepared via N-oxidation followed by either nitration or arylation in the yield of 60-80%. Substitution at 2- position is promoted due to the electron withdrawing and meta- directing ability of acetyl group at 4- position making the pyridine N-oxide vulnerable to attack at C-2.

Keywords:
4- acetyl pyridine, N-oxidation, nitration, arylation, nuclear substitution.

How to cite : Pradhan J, Goyal A, Synthesis of some nuclear substitution derivatives of 4-acetyl pyridine. Int J Pharm Chem Anal 2015;2(3):113-119

Copyright © 2015 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)