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IP International Journal of Periodontology and Implantology


Estimation of Beta-CTXin gingival crevicular fluid and serum of periodontally healthy individuals and chronic periodontitis patients before and after non-surgical periodontal therapy- An in-vivo study


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Research Article

Author Details : Anisha Yadav*, Anita Kulloli, Sharath Shetty, Santosh Martande

Volume : 4, Issue : 3, Year : 2020

Article Page : 92-97


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Abstract

Objective and Design: Beta Cross-linked C-terminal telopeptide of type I collagen (fragment β- CTX) is newer addition to the list of bone resorption markers in serum. The purpose of our study was to estimate and compare the levels β-CTX in gingival crevicular fluid (GCF) and serum of periodontally healthy individuals and chronic periodontitis (CP) patients before and after nonsurgical periodontal therapy (NSPT).
Materials and Methods: Twenty Five subjects with equal distribution of males and females were divided into two groups i.e Group I: 10 Periodontally healthy individuals, Group II: 15 CP patients aged between 30-50 years. GCF and serum samples were collected at baseline in Group I whereas in Group II GCF and serum samples were collected at baseline and 2 months after NSPT. The levels of GCF and serum β-CTX were quantified using enzyme-linked immunosorbent assay (ELISA). The clinical parameters evaluated were plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) and the correlations of β-CTX in GCF and serum with clinical parameters were evaluated.
Results: The mean concentration of β-CTX increased from Group I to Group II. The mean concentration of β-CTX in GCF and serum was reduced after 2 months of NSPT. Furthermore, reduction in β-CTX levels was positively correlated to gain in CAL in GCF.
Conclusion: Periodontal treatment resulted in the reduction of β-CTX levels suggesting that β- CTX can be considered as a potential marker of bone resorption in CP.

Keywords: Collagen, Gingival Crevicular Fluid, C-terminal telopeptide, Chronic Periodontitis, Bone Resorption, Bone turnover Marker.

Doi : 10.18231/j.ijpi.2019.020

How to cite : Yadav A, Kulloli A, Shetty S, Martande S, Estimation of Beta-CTXin gingival crevicular fluid and serum of periodontally healthy individuals and chronic periodontitis patients before and after non-surgical periodontal therapy- An in-vivo study. IP Int J Periodontol Implantol 2020;4(3):92-97

Copyright © 2020 by author(s) and IP Int J Periodontol Implantol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)