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IP International Journal of Periodontology and Implantology


Therapeutic evaluation of local drug delivery system containing 1.5% chlorhexidine used as an adjunct to scaling and root planing for the treatment of chronic periodontitis - A clinical and microbiologcal study


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Research Article

Author Details : Randhir Kumar, Geeta Sharma*

Volume : 4, Issue : 3, Year : 2019

Article Page : 103-106


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Abstract

Periodontitis has a multifactorial etiology with primary etiologic agents being pathogenic bacteria that reside in the subgingival area. Local delivery devices are systems designed to deliver agents locally into periodontal pocket to retain therapeutic levels for a prolonged period of time.
Review of Literature: Goodson et al (1979)1 introduced the use of tetracycline as a local drug delivery component in the treatment of periodontal diseases. W.A. Soskolne, P.A. Heasman, and H.N. Newman (1997)5 conducted a multicenter study to evaluate the safety and efficacy of a degradable, subgingivally placed drug delivery system containing 2.5 mg Chlorhexidine were evaluated in a randomized, blinded, multi-center study.
Aims and Objective: The aims of the present study is to compare the effect of experimental local drug delivery system containing 1.5% chlorhexidine (chlorhexidine digluconate 0.5% and chlorhexidine dihydrochloride1%) with scaling and root planing and scaling and root planing alone by assessing the effect on: Plaque, Gingival Inflammation, Bleeding on probing, Pocket depth, Relative attachment levels, Percentage of spirochetes, motile rods and coccoid cells.
Materials and Methods: A total of 30 subjects comprising of both the sematerxes and diagnosed as suffering from chronic localized or generalized periodontitis.
Recording of Clinical and Microbiological Parameters: Plaque index, gingival index, Pocket depth measurement using William's graduated probe using acrylic stent.
Microbiological study of collected plaque sample for coccoids, rods and spirochetes under dark field microscopy. The above clinical and microbiological parameters were recorded on: 0 day, 30th day, 45th day.
Statistical Analysis: Post treatment changes from baseline to different time intervals in various clinical parameters were analyzed by paired t-test (Intragroup). Intergroup comparisons of post-treatment changes were analyzed by unpaired t-test. p-value <0>
Results and Discussion: At the selected sites clinical and microbiological parameters were recorded at base line, 30th day and 45th day, as per the study design. The experimental material along with scaling and root planing is found to be more effective than scaling and root planing alone when evaluated clinically and microbiologically. This effect may be due to antimicrobial and anti-plaque property of the experimental material.

Keywords: Periodontitis, Local drug delivery system, Chlorhexidine scaling.

Doi : 10.18231/j.ijpi.2019.022

How to cite : Kumar R, Sharma G, Therapeutic evaluation of local drug delivery system containing 1.5% chlorhexidine used as an adjunct to scaling and root planing for the treatment of chronic periodontitis - A clinical and microbiologcal study. IP Int J Periodontol Implantol 2019;4(3):103-106

Copyright © 2019 by author(s) and IP Int J Periodontol Implantol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)