COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 164

Article download: 86

IP Journal of Paediatrics and Nursing Science

A case report on HLH in a rural area- A missed diagnosis, challenges and recommendations

Full Text PDF Share on Facebook Share on Twitter

Case Report

Author Details : Likhita Shaik*, Sagar Mhetre, Sunil Vaidya

Volume : 2, Issue : 3, Year : 2019

Article Page : 81-84

Suggest article by email


“Hemophagocytic lymphohistiocytosis (HLH) is a histiocytic disorder characterized by a highly stimulated, but ineffective, immune response to antigens, which results in a fatal cytokine storm with an inflammatory reaction”. It is often underdiagnosed due to its vague presentation and similarities it shares with a spectrum of other diseases. To add to the obstacles, ruling out each causative mechanisms include underlying genetic defects as well as “trigger” factors, such as infections, malignancies, and autoimmune disorders consumes time and hence delays the diagnosis and treatment. Inspite of various advances in genetic testing and analysis diagnosis becomes a challenging event when it occurs in rural areas where very little is known about it. Here we present a case of a 2 month old female presenting with fever, decreased appetite and excessive irritability. The various parts of the Case report highlights the aspects of every barrier that came across to reach the diagnosis. Moreover, it also adds on how the perplexity of the social concerns limit the ability to obtain essential health care and thus paving way for some amendments that can be made to improve the healthcare status in rural areas.

Keywords: FHLH, Health care, HLH, Hemophagocytic lymphohistiocytosis, Rural areas, Recommendations, Reforms, SHLH.

How to cite : Shaik L, Mhetre S, Vaidya S, A case report on HLH in a rural area- A missed diagnosis, challenges and recommendations. J Paediatr Nurs Sci 2019;2(3):81-84

Copyright © 2019 by author(s) and J Paediatr Nurs Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (