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Indian Journal of Pathology and Oncology

Pleomorphic adenoma in lacrimal gland: Histopathological study

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Research Article

Author Details : Pratik Desai*, Ami Shah

Volume : 6, Issue : 4, Year : 2019

Article Page : 647-651

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Introduction: The lacrimal gland is non-capsulated, multilobulated secretory gland situated in the lacrimal
gland fossa. Lesion and tumors of lacrimal gland occupy almost 18% of all orbital tumors. Pleomorphic
adenoma of lacrimal gland also known as mixed tumour of lacrimal gland it is the most common tumor as
well as most common benign tumor of lacrimal gland and very critical to differentiate between adenocystic
and pleomorphic adenoma of lacrimal gland because of different prognosis.
Aims and Objectives: To study the prevalence of pleomorphic adenoma in to the lacrimal gland tumors
and to study the histopathological pattern of pleomorphic adenoma in lacrimal gland, its distribution into
the age, sex and its outcome in to different condition.
Materials and Methods: A retrospective study of 38 cases of pleomorphic adenoma in lacrimal gland
during period of 10 years were studied at tertiary care institute. A detailed history of patients were taken
with special attention to the age, sex, macroscopic (gross examination) and microscopic features of tissue.
Microscopic examination is done under standard H & E staining procedure. Microscopic examination is
focused on specifically tumour cells size, shape, nucleus characteristics and cytoplasm and arrangement of
Result: Total 57 cases of lacrimal gland tumor were studied among them 38 cases (66.66%) of pleomorphic
adenoma were diagnosed. Among 38 cases of pleomorphic adenoma 26 cases (68.4%) were in Female and
12 cases (31.6%) were in male. Among them most number of cases are seen in the age group of 21-40
years almost 18 cases (47.3%), and second common frequency in to the 41-60 years age group contain
13 cases (34.2%). When studied according to histological features, then Myxoid differentiation are seen
in 33 (94%)cases, Squamous metaplasia are seen in 18 cases(47%), Chondroid differentiation are seen in
16 cases(42%), Cystic degeneration are seen in 12 cases (33%), Calcification are seen in 3 cases (8%),
Cellular atypia are seen in 2 cases(6%), Osseous metaplasia is seen in 1 case (2.6%), Hy aline changes are
seen S in 17 cases (45%), Predominantly cellular appearance in 21 cases (55.2%), Predominantly stromal
appearance in 1 cases (2.6%), Mixed (cellular + stromal) 3 cases (7.9%).
Conclusion: Pleomorphic adenoma is most common benign tumour of lacrimal gland tumour and its
incidence are significantly higher into the female (68.4%) and most common presenting age group is 21-40
(47.3%) and if bar is raised to 21-60 years then almost 80% cases fall in this category so most commonly
seen in middle age group.

Keywords: Pleomorphic adenoma, Lacrimal gland, Histological features, Age.

Doi : 10.18231/j.ijpo.2019.124

How to cite : Desai P, Shah A, Pleomorphic adenoma in lacrimal gland: Histopathological study. Indian J Pathol Oncol 2019;6(4):647-651

Copyright © 2019 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (