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Indian Journal of Pathology and Oncology

A histomorphological study of meningiomas with relation to Ki-67 proliferative index and review of literature

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Research Article

Author Details : Rashmi Raveendran*, S Ganthimathy

Volume : 6, Issue : 4, Year : 2019

Article Page : 682-687

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Objective: The revised 4th edition of the WHO classification of tumours of the central nervous system
categorizes meningiomas into three grades based on their histomorphology. However, the biological
behaviour and recurrence rates for these tumours cannot be predicted using morphology alone. The aim of
the study was to study the demography of Meningiomas and to correlate the grade with the Ki-67 Labelling
Index (LI) and compare them to tumour recurrence.
Materials and Methods: The study included 38 cases of Meningioma of various subtypes. Hematoxylin
and Eosin slides were reviewed; appropriate blocks were sectioned and stained with Immunohistochemical
marker, Ki-67. Slides were studied and Ki-67 labelling index was calculated.
Results: The tumour was more common in the female population and in the 5th and 6th decades of life.
The average Ki67 labelling index showed insignificant variation among tumours within the same grade (p=
0.15) but demonstrated considerable disparity with increasing grades (p < 0> of recurrence of a previous Papillary Meningioma, with a Ki-67 index of 25.32.
Conclusion: Ki67 labelling index in meningiomas increases in proportion to increasing grade and is a
good indicator of tumour recurrence. Some histologically benign tumours have been known to recur after
complete excision. Hence, we suggest that immunohistochemistry for Ki-67 LI should be done for all cases
of meningioma, irrespective of the type.

Keywords: Meningioma, Ki 67, Tumor, Grade, CNS.

Doi : 10.18231/j.ijpo.2019.129

How to cite : Raveendran R , Ganthimathy S, A histomorphological study of meningiomas with relation to Ki-67 proliferative index and review of literature. Indian J Pathol Oncol 2019;6(4):682-687

Copyright © 2019 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (