COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Covid Alert


Print ISSN:-2394-6784

Online ISSN:-2394-6792

CODEN : IJPOF3

Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 96

Emailed: 0

PDF Downloaded: 76

Indian Journal of Pathology and Oncology


Consortum between mast cell and prostatic lesions-An etiological factor or mere coexistence


Full Text PDF Share on Facebook Share on Twitter


Research Article

Author Details : Vani D, Kumari Bhuvaneshwari S A*, Bharathi M

Volume : 7, Issue : 1, Year : 2020

Article Page : 171-175


Suggest article by email


Abstract

Introduction: Prostate cancer exhibits a complex genetic and heterogeneous histological pattern reflecting
its multifactorial phenotype. Mast cells mainly known for their role in allergy and anaphylaxis, now
regarded as key factor cell in angiogenesis, tissue remodeling and repair, whereas their importance in
tumor pathology as either cancer promoter or inhibitor is still debated.
Materials and Methods: Study included 100 cases of prostatic lesions with 74 cases of benign prostatic
lesions and 26 cases of adenocarcinoma prostate, received in the form of transurethral resection of prostate
chips for histopathological examination. The tissues were routinely processed, the paraffin sections stained
by hematoxylin and eosin and 1% toluidine blue. Histological diagnosis was made. Mast cell count was
done taking a standard of 10 high power fields(x40) and mean were calculated. Distributions of mast cells
were noted in stroma, perivascular, periglandular and intraglandular regions.
Results: Mast cell count was significantly higher in benign prostatic hyperplasia with mean of 3.6 per high
power field whereas absence or low count was found in adenocarcinoma prostate with mean of 1.7 per high
power field. Mast cells were located predominantly in stromal region in both BPH and adenocarcinoma
prostate; in rest of the areas the numbers were comparable.
Conclusion: In this study we observed significant increase in mast cell count in stroma of BPH compared
to adenocarcinoma indicating that mast cell density is inversely proportional to malignancy. This suggests
high mast cell count favors the prognosis.

Keywords: Mast cells, Benign Prostatic Hyperplasia, Adenocarcinoma.

Doi : 10.18231/j.ijpo.2020.032

How to cite : Vani D, Kumari Bhuvaneshwari S A, Bharathi M, Consortum between mast cell and prostatic lesions-An etiological factor or mere coexistence. Indian J Pathol Oncol 2020;7(1):171-175

Copyright © 2020 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)