COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Article view: 619

Article download: 126

Indian Journal of Pathology and Oncology


Profile of Patients with Thrombosis Evaulauted in a Tertiary Care Centre


Full Text PDF Share on Facebook Share on Twitter


Author Details : Aysha Ali, Prasanna N Kumar, G. Uma Maheshwari

Volume : 3, Issue : 1, Year : 2016

Article Page : 77-81


Suggest article by email


Abstract

Background: Venous and Arterial thrombosis are common diseases with an annual incidence of 1 in 1000 per year (1). Several risk factors have been identified like increased levels of coagulation factors –factor VIII,IX,XI,II and fibrinogen which are cumulatively explored by APTT(activated partial thromboplastin time). Elevated factor VIII levels are identified as an independent risk Antiphospholipid antibody syndrome, paroxysymal nocturnal hemoglobinuria, sickle cell disease are also associated with strong tendency for thrombosis.
Objectives: (A) To examine the risk factors involved in the pathogenesis of thrombosis in Indian population.
(B) To investigate the significance of these risk factors in incidence of venous and arterial thrombosis.
Materials: Blood samples were collected from patients presenting with clinical picture of arterial or venous thrombosis for routine tests. The following tests were done on the samples: complete blood count, sickling test, Ham’s acidified serum test, Sucrose lysis test, prothrombin time, activated partial thromboplastin time, lupus anticoagulant assay (dRVVT based), Factor VIII:C assay, anti cardiolipin antibody
Results: 310 cases were analysed. 124 patients(40.0%) had presented with proximal and dsital venous thrombosis, 68 patients with recurrent abortions (21.9%), 38 CASES(12.7%) ischemic heart disease and 43 cases (14.3%)with cerebrovascular disease, There were 11 cases of vasculitis (3.7%),10 cases of arterial thrombosis and 16 cases of pulmonary thromboembolism (5.3%). Increased factor VIII: c levels was the commonest risk factor identified followed by Antiphospholipid antibody (23.5%) and shortened APTT. No risk factors were identified in 50.6 % of the cases. There was one case each of sickle cell anemia and paroxysymal nocturnal hemoglobinuria who presented with pulmonary embolism and portal vein thrombosis respectively.
Conclusion: The commonest risk factor identified was increased factor VIII: C levels, The presence of antiphospholipid antibodies was found to be linked with ischemic heart disease and venous and arterial thrombosis. There was also a very significant association between the presence of antiphospholipid antibodies, lupus anticoagulant and anticardiolipin antibodies with recurrent abortions. There was a correlation between the shortening of APTT and incidence of venous thromboembolism in this study. This study also showed that APTT is not an optimal screening test for detecting lupus anticoagulants.

How to cite : Ali A, Kumar P N, Maheshwari G U, Profile of Patients with Thrombosis Evaulauted in a Tertiary Care Centre. Indian J Pathol Oncol 2016;3(1):77-81

Copyright © 2016 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)