COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Covid Alert


Print ISSN:-2394-6784

Online ISSN:-2394-6792

CODEN : IJPOF3

Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 548

Emailed: 0

PDF Downloaded: 153

Indian Journal of Pathology and Oncology


A study of Ki 67 immunostaining in breast carcinomas: Correlation with histopathological prognostic factors


Full Text PDF Share on Facebook Share on Twitter


Author Details : Shetageri Shruthi Neelakanth, Satish Suchitha, Vimalambika Gubbanna Manjunath

Volume : 4, Issue : 1, Year : 2017

Article Page : 98-102


Suggest article by email


Abstract

Background: One of the most common causes of carcinoma deaths among women is breast cancer. In view of the above, early diagnosis and effective treatment of the disease are immensely important. The increasing number of options for the treatment of breast cancer has made the prognostic evaluation of the disease even more important. Proliferation plays an important role in the clinical behaviour of invasive breast cancer. Ki 67 binding, is an objective measurement of cell proliferation which significantly aids in the management of the breast cancer patients.

Objectives:

1.        To study the proliferative activity using Ki 67 immunostaining in breast carcinoma.

2.        To assess the relationship of Ki 67 scores with size, histological grade and lymph node status.                    

Methods: Seventy five cases of histologically proven breast carcinomas were studied. Histopathological grade was assessed using Bloom and Richardson’s method, modified by Elston and Ellis. Immunohistochemistry (IHC) for Ki 67 was done on paraffin embedded wax sections.
Results: Ki 67 was positive in 73/75 cases (97.33%). The range of Ki 67 score was 0 to 90%. Mean value of Ki 67 was 31.86% and median was 30%. A statistically significant correlation was observed between size (P=0.037), grade (P < 0.0001) and Nottingham Prognostic Index (P < 0.0001) with Ki 67 scores.
No statistically significant correlation was seen with lymph node status (P=0.767), lymphovascular invasion, necrosis, presence of desmoplasia, ductal carcinoma in situ (DCIS), nipple and areola involvement.
Conclusion: Proliferation has been recognized as a distinct hallmark of cancer and acts as an important determinant of cancer outcome. As Ki 67 can be used to objectively measure this, it can be included in the pool of prognostic markers like tumor size, nodal status, histopathological grade and hormonal receptors.

Keywords: Breast Carcinoma, Ki 67, Size, Grade, Lymph node status

How to cite : Neelakanth S S, Suchitha S, Manjunath V G, A study of Ki 67 immunostaining in breast carcinomas: Correlation with histopathological prognostic factors. Indian J Pathol Oncol 2017;4(1):98-102

Copyright © 2017 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)