COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Covid Alert

Print ISSN:-2394-6784

Online ISSN:-2394-6792


Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 544

Emailed: 0

PDF Downloaded: 150

Indian Journal of Pathology and Oncology

Comparative Immunohistochemical Analysis of Ki -67 in a Spectrum of Pediatric Solid Tumours

Full Text PDF Share on Facebook Share on Twitter

Author Details : GA Vasugi, Sandhya Sundaram, Lawrence D’cruze, Aruna Rajendran, Julius Xavier Scott

Volume : 4, Issue : 4, Year : 2017

Article Page : 570-574

Suggest article by email


Introduction: The aim of this study is to analyse the clinicopathological profile of malignant pediatric solid tumours and also to evaluate the proliferative index using Ki-67 in a spectrum of these tumours.
Materials and Method: 75 cases of malignant solid tumours age group less than 17 years, reported at Sri Ramachandra Medical College from Jan 2009 to Dec 2013 are included in this study. Formalin fixed paraffin embedded tissue stained with H&E were used for routine morphology. Immunohistochemical staining was done using monoclonal anti Ki 67 antibody by Streptavidin biotin peroxidase complex technique. Labelling index or growth fraction is calculated as the percentage of positive cells for 1000 cells evaluated.
Results: Among the 75 cases 52 (68%) were males and 23(32%) were females. 22(29%) were CNS neoplasms and 53(71%) were Non CNS neoplasms which included lymphoma, Ewing’s sarcoma, Osteosarcoma, Wilms tumour, Soft tissue tumours, Germ cell tumours, Neuroblastoma, Hepatoblastoma & others. The labelling index was variable according to the grade of the tumours. It varied from 2 to 40% in CNS neoplasms according to the grade and about 1 to 90% in various Non CNS neoplasms.
Conclusion: Pediatric solid tumours form a wide spectrum. Ki-67 labelling index may be a useful adjunct in predicting the biological behaviour & prognosis of pediatric solid tumours.

Ki-67, Pediatric solid tumours, prognosis

How to cite : Vasugi G, Sundaram S, D’cruze L, Rajendran A, Scott J X, Comparative Immunohistochemical Analysis of Ki -67 in a Spectrum of Pediatric Solid Tumours. Indian J Pathol Oncol 2017;4(4):570-574

Copyright © 2017 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (