COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 590

Article download: 188

Indian Journal of Pathology and Oncology

Study of dimorphic anemia in adults with reference to basic etiology

Full Text PDF Share on Facebook Share on Twitter

Author Details : Deepthi. A, CSBR Prasad, Raghavendra Prasad B. N.

Volume : 5, Issue : 1, Year : 2018

Article Page : 61-66

Suggest article by email


Objective: To investigate the basic cause of dimorphic anemia in adult patients using hematological parameters, bone marrow iron stores, serum vitamin B12 and folate assays.
Materials and Methods: Hematological parameters and bone marrow, serum vitamin B12 and folate assays of 62 patients with dimorphic anemia were studied to evaluate the basic etiology in dimorphic anemia.
Results: The mean MCV was 95.01±13.14fl and MCV was normal in 56.45% cases. BM examination showed megaloblastic maturation in 32.36%, megaloblastic with micronormoblastic maturation in 64.52% cases. BM iron stores were deficient in 32.26% cases. 43.55% cases had only folic acid deficiency, 19.35% cases had only B12 deficiency and 27.42% cases had both B12 and folate deficiency. Combined iron and vitamin deficiencies in 25.8% cases. The mean MCV, MCH, MCHC and RDW were significantly high in combined deficiencies.
Conclusion: The common basic cause for dimorphic anemia was folate deficiency. MCV is unreliable as a screening parameter for anemia with vitaminB12 or folate deficiencies. Concomitant deficiencies of B12 or folate with iron deficiency are not infrequent; one type of anemia may mask the other. Serum assays will be appropriate to establish the cause in cases with concomitant deficiencies, as it may result in discordant results with various other tests like hematological parameters.

Keywords: Anemia, Dimorphic, Folate, Megaloblastic, Myelodysplasia, Vitamin B12.

Doi : 10.18231/2394-6792.2018.0012

How to cite : Deepthi. A, Prasad C, Raghavendra Prasad B. N., Study of dimorphic anemia in adults with reference to basic etiology. Indian J Pathol Oncol 2018;5(1):61-66

Copyright © 2018 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (