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Indian Journal of Pathology and Oncology


Space occupying lesions of central nervous system: A radiological-histopathological correlation study


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Author Details : Sunila, Kumarguru. B.N., T S Vasan, Manjunath. G.V.

Volume : 5, Issue : 2, Year : 2018

Article Page : 202-207


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Abstract

Introduction: Radiological imaging modalities are important pre-operative diagnostic tools to detect the central nervous system [CNS] lesion. Radiological findings can be used by pathologists to narrow down the differential diagnoses. Radiological diagnosis requires confirmation by histopathology
Aims: 1. To study various patterns of central nervous system [CNS] lesions in histopathology.
2. To correlate radiological diagnosis with histopathological diagnosis.
3. To evaluate the diagnostic efficacy of radiological diagnosis.
Settings and Study Design: Analytical study at tertiary care hospital.
Materials and Methods: Eighty eight cases were analyzed. Histopathological evaluation was done from biopsy samples sent in formalin. Tissue processing was done by standard operating procedure. Tissue sections were routinely stained by H&E. Special stains were performed in selected cases. Radiological diagnosis was correlated with histopathological diagnosis and concordance was calculated.
Statistical Analysis: Frequencies, Chi-Square Test and Crosstabs were used for calculation.
Results: Histopathological diagnosis of eighty eight cases included neoplastic lesions [90.9%] and non-neoplastic lesions [9.09%]. Correct diagnosis was achieved by radiology in 36 cases [45%] by complete concordance. However, diagnostic accuracy improved considerably [85%] after applying partial concordance criteria. For the detection of neoplastic lesions, radiological diagnosis had sensitivity of 96.25%, specificity of 50% and efficacy of 92.04%. The p value, determining efficacy of radiological investigations for detecting CNS neoplasms was statistically significant [p<0.005].
Conclusions: Radiological investigation is a reliable diagnostic tool for space occupying central nervous system lesions. It has high sensitivity and is highly efficacious investigative modality.

Keywords: Biopsy, Neoplasms, Tissue.

Doi : 10.18231/2394-6792.2018.0038

How to cite : Sunila, B.n. K, Vasan T S, G.v. M, Space occupying lesions of central nervous system: A radiological-histopathological correlation study. Indian J Pathol Oncol 2018;5(2):202-207

Copyright © 2018 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)