COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 388

Article download: 247

Indian Journal of Pathology and Oncology

Clinico-pathological evaluation of non-neoplastic and neoplastic skin lesions: A study of 100 cases

Full Text PDF Share on Facebook Share on Twitter

Author Details : Gireesh V. Achalkar

Volume : 6, Issue : 1, Year : 2020

Article Page : 118-122

Suggest article by email


Introduction: Skin is the largest organ among all the organs of the body. The clinical manifestations of diseases of skin are vary in nature both in clinical presentations and behavior. It is necessary to cross talk between pathologist and dermatologist for better management of patients. Histopathological examination plays a significant role and the gold standard in providing accurate diagnosis for a variety of skin lesions.
Objective: 1. To evaluate histopathology as an ideal diagnostic method for vesiculobullous (non–neoplastic) and neoplastic (tumourous) skin lesions. 2. To establish the correlation between the microscopic pathological findings of various skin lesions with the presenting clinical features.
Materials and Methods: 100 patients of skin diseases were included for the study. Punch, excisional or incisional biopsy techniques were used to get the tissues. The tissue was obtained for detailed histopathological examination. The histological sections were stained with hematoxylin and eosin stains and histochemical stains were used as supplementary diagnostic tool.
Results: Out of 100 patients, 54% had vesiculobullous lesions, 22% granulomatous morphology and 24% were neoplastic. Epidermoid cysts included in benign neoplasm category and accounted for 37.5% of neoplasms. Squamous cell carcinoma was the most common malignant tumor (52.8%).
Conclusion: Histopathological study of skin biopsies helps to make an early and accurate clinically useful diagnosis in almost all of the normal looking or vesiculobullous or non neoplastic and neoplastic skin lesions, as the study of microscopic morphological features of different types of skin lesions had differentiating findings under the microscope.

Keywords: Vesiculobullous lesions, Histopathology, Pemphigus, Herpes.

Doi : 10.18231/2394-6792.2019.0021

How to cite : Achalkar G V, Clinico-pathological evaluation of non-neoplastic and neoplastic skin lesions: A study of 100 cases. Indian J Pathol Oncol 2020;6(1):118-122

Copyright © 2020 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (