COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Covid Alert

Print ISSN:-2394-6784

Online ISSN:-2394-6792


Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 412

Emailed: 0

PDF Downloaded: 189

Indian Journal of Pathology and Oncology

Histomorphologic study of cystoscopic urinary bladder biopsies: A gold standard

Full Text PDF Share on Facebook Share on Twitter

Research Article

Author Details : Anupama Praveen Gupta*, Anuradha Gupta, Dinkar T. Kumbhalkar

Volume : 6, Issue : 2, Year : 2019

Article Page : 174-181

Suggest article by email


Introduction: Urinary bladder lesions pose significant morbidity and mortality throughout the world. Cystoscopy, a widely accepted technique for diagnosing lower urinary tract lesions has its own limitations. Histopathology is gold standard for diagnosing, staging and to assess the microscopic invasion in malignant lesions. Thus present study was undertaken to study bladder biopsies and to correlate cystoscopic impression with histopathology and to know depth of invasion in malignant lesions.
Materials and Methods: It is an observational, prospective study of sixty cystoscopic guided urinary bladder biopsy done at tertiary care hospital over two year period.
Results: Out of total sixty biopsies 19 were non neoplastic (8 inflammatory, 9 metaplastic and 2 immune mediated) and 41 were neoplastic (2 benign, 39 malignant) on histopathology. Non neoplastic lesions (19/60) comprised of 4 follicular cystitis, 2 tuberculous cystitis, 2 eosinophilic cystitis. 4 cystitis cystica, 4 squamous metaplasia, one nephrogenic metaplasia and 2 amyloidosis. Neoplastic group (41/60) comprised of one papilloma, one papillary neoplasm of low malignant potential (PUNLMP), 28 transitional cell carcinoma (TCC), 3 adenocarcinoma, 6 squamous cell carcinoma, one small cell carcinoma and one embryonal RMS. Muscle invasion was detected in 8 and vascular invasion in 2 cases respectively. Cystoscopic impression was non neoplastic and neoplastic in 14 /60 and 46/60 respectively accounting for five discordant cases where final diagnosis was offered on histopathology.
Conclusion: Cystoscopy and histopathological examinations are complementary to each other in evaluating bladder pathologies but histology remains gold standard.

Keywords: Cystoscopy, Urinary bladder, Biopsy, Histopathology, Transitional cell carcinoma.

Doi : 10.18231/j.ijpo.2019.034

How to cite : Gupta A P, Gupta A, Kumbhalkar D T, Histomorphologic study of cystoscopic urinary bladder biopsies: A gold standard. Indian J Pathol Oncol 2019;6(2):174-181

Copyright © 2019 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (