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Year 2020

Volume: 7 , Issue: 2

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Indian Journal of Pathology and Oncology

CNS malformations in perinatal autopsy

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Research Article

Author Details : Anita A. M, Priyanka Patil*, Anusha Kulkarni, Anuradha G. Patil

Volume : 6, Issue : 3, Year : 2019

Article Page : 406-412

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Aim: The aim of the present study is to examine the different malformations of Central Nervous System in perinatal autopsy and to study other associated lesions/syndromes if any.
Materials and Methods: This study includes perinatal autopsies carried out in the pathology department of a tertiary care centre over a period of two years from June 2016 to May 2018.Total 200 perinatal autopies were performed after taking informed consent of parents according to standard protocol.
Results: Out of 200 perinatal autopsies 14 cases showed rare CNS malformationin which 9 cases were associated with other anomalies. All the cases were of intrauterine death (induced or spontaneous). Gestational age ranged between 12-40 weeks. Weight of the foetuses ranged between 500g-2000g.
Conclusion: Even though the prenatal ultrasonogram reasonably predicts the malformations, autopsy at times provides additional information and to confirm the diagnosis or indicate a syndrome. Primary prevention of CNS malformations can be improved in our country by proper antenatal checkups, maternal nutrition (folic acid supplementations) and genetic counselling plays a vital role in reducing the congenital malformations (in particular CNS) and future recurrences.

Keywords: Central nervous system, Malformations, Perinatal autopsy.

Doi : 10.18231/j.ijpo.2019.078

How to cite : Anita A. M, Patil P, Kulkarni A, Patil A G, CNS malformations in perinatal autopsy. Indian J Pathol Oncol 2019;6(3):406-412

Copyright © 2019 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (