Print ISSN:-2393-9079

Online ISSN:-2393-9087

CODEN : IJPPTK

Current Issue

Year 2019

Volume: 6 , Issue: 4

Article view: 750

Article download: 238

Indian Journal of Pharmacy and Pharmacology


The study of antiepileptic activity of clove oil by MES model in mice


Full Text PDF Share on Facebook Share on Twitter


Author Details : Avanthi E, Pradeep Kumar L, Lokesh BN, Yadavalli Guruprasad

Volume : 3, Issue : 3, Year : 2016

Article Page : 103-107


Suggest article by email


Abstract

Background: The objective was to evaluate and compare the effect of extract of essential oil of clove with the standard sodium valproate on MES model.
Methods: A total of thirty mice were taken, they were given an electroconvulsive shock. Thirty mice were divided into five groups of six animals each, the control group received distilled water 5ml/kg i.p, standard received Inj. Sodium valproate 200 mg/kg i.p. another group received Sesame oil – 10ml/kg i.p(control), test groups received Clove oil- 0.075 ml/kg i.p., Clove oil-0.1ml/kg i.p respectively. All the injections were given 30 minutes before the test.
Results: Clove oil produced significant antiepileptic effect at all the doses.
Conclusion: Clove oil has shown significant antiepileptic activity in mice.

Keywords:
Epilepsy, Clove oil, Albino mice, MES model

How to cite : Avanthi E, Pradeep Kumar L, Lokesh Bn, Guruprasad Y, The study of antiepileptic activity of clove oil by MES model in mice. Indian J Pharm Pharmacol 2016;3(3):103-107

Copyright © 2016 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)