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Indian Journal of Pharmacy and Pharmacology


A QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDY OF AZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY


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Author Details : Mallikarjun B Katte, Jagadishchandra S Ratnakar, Lopamudra Banerjee

Volume : 2, Issue : 1, Year : 2015

Article Page : 1-5


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Abstract

It was reported that some 3-amino 2-aryl-1-azolyl-2-butanol have antifungal effects. To understand the structural basis for antifungal activity and guide in the design of more potent agents, we performed quantitative structure activity. The Minimum Inhibitory Concentration (MIC) values of 3-amino-2-aryl-1-azolyl-2-butanol on yeast exhibited a strong correlation with the prediction made by the model developed in the present study. The statistical results of the Training Set, Regression coefficient r (0.841648) and r2 (0.708371) values gave reliability to the prediction of inhibitory activity of a series of Azole derivatives.

Key words: Anti-fungal, Azole, Quantitative Structure Activity Relationship.

How to cite : Katte M B, Ratnakar J S, Banerjee L, A QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDY OF AZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY. Indian J Pharm Pharmacol 2015;2(1):1-5

Copyright © 2015 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)