COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Print ISSN:-2393-9079

Online ISSN:-2393-9087


Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 672

Emailed: 0

PDF Downloaded: 245

Indian Journal of Pharmacy and Pharmacology

Study of prescription pattern and adverse drug reactions of antineoplastic drugs in patients with breast cancer in a tertiary care teaching hospital

Full Text PDF Share on Facebook Share on Twitter

Author Details : Renuka L. Kadam, Vijay M.Motghare, Smita Sontakke, Vijay Mahobia, A.K. Diwan

Volume : 4, Issue : 4, Year : 2017

Article Page : 210-214

Suggest article by email


Introduction: To study current prescription pattern of drugs and adverse drug reactions (ADRs) in patients of carcinoma breast.
Methodology: This observational, cross-sectional study was carried out in Radiotherapy department of a tertiary care teaching hospital for a period of two months. Patients diagnosed with breast carcinoma and attending Radiotherapy department for chemotherapy were included. Prescriptions were analysed and details of drugs prescribed were recorded. Patients were enquired about occurrence of any ADRs and details were recorded. Preventability and severity of ADRs were assessed by modified Schumock and Thornton scale and modified Hartwig and Siegel scale respectively.
Results: A total of 70 patients were included in the study. Cyclophosphamide was the most commonly used chemotherapeutic agent (77.14%), followed by Doxorubicin (68.57%) and 5-FU (44.29%). Most commonly prescribed regimen was Cyclophosphamide + 5FU + Doxorubicin followed by Cyclophosphamide + Doxorubicin. Nausea was the most commonly reported ADR followed by alopecia, vomiting and blackening of nails. Maximum ADRs were reported with Cyclophosphamide + Doxorubicin + 5 FU combination followed by Cyclophosphamide + Doxorubicin combination. Out of the total ADRs 60.11% belonged to the category of “definitely preventable” while 74.15% of ADRs were of less severity categorized as “mild level 1” severity.
Conclusion: Cyclophosphamide was the most commonly prescribed drug. Highest incidence of ADRs was observed with Cyclophosphamide + Doxorubicin + 5 FU. Inspite of prophylactic antiemetic treatment majority of patients had nausea and vomiting which indicates that more vigorous measures to prevent emesis need to be undertaken since these ADRs of antineoplastic drugs are usually preventable.

Keywords: Carcinoma breast, Anticancer drugs, Adverse drug reaction

How to cite : Kadam R L, M.motghare V, Sontakke S, Mahobia V, Diwan A, Study of prescription pattern and adverse drug reactions of antineoplastic drugs in patients with breast cancer in a tertiary care teaching hospital. Indian J Pharm Pharmacol 2017;4(4):210-214

Copyright © 2017 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (