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Indian Journal of Pharmacy and Pharmacology


In-Vivo Antioxidant Activity of Different Fractions of Michelia Nilagirica against Paracetamol Induced Toxicity in Rats


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Author Details : Aminabee SK, Lakshmana Rao A, Chinna Eswaraiah M

Volume : 2, Issue : 3, Year : 2015

Article Page : 176-182


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Abstract

Objective: To evaluate the in-vivo antioxidant potential of ethanolic extract of whole plant of Michelia nilagirica against paracetamol induced toxicity in rats.
Methods: Animals were treated with ethanolic plant extract for 7 days and the toxicity was induced with a single dose of paracetamol intraperitoneal injection. Pre-treatment with 70 mg/kg p.o of ethanolic extract of whole plant of Michelia nilagirica improved the SOD, catalase, peroxidase and glutathione levels significantly as compared to control group.
Results: The present study revealed that Michelia nilagirica has significant in-vivo antioxidant activity and can be used to protect tissue from oxidative stress. The results showed that the activities of SOD, catalase, peroxidase and glutathione in group treated with paracetamol, declined significantly than that of normal group.
Conclusion: Ethanolic extract of whole plant of Michelia nilagirica in the dose of 60 mg/kg, p.o. has improved the SOD, catalase, peroxidase and glutathione levels significantly. Based on this study we conclude that ethanolic extract of whole plant of Michelia nilagirica possesses in-vivo antioxidant activity and can be employed in protecting tissue from oxidative stress.

Keywords: Michelia nilagirica, Paracetamol, Sylimarin, Radical scavenging.

How to cite : Aminabee Sk, Lakshmana Rao A, Chinna Eswaraiah M, In-Vivo Antioxidant Activity of Different Fractions of Michelia Nilagirica against Paracetamol Induced Toxicity in Rats. Indian J Pharm Pharmacol 2015;2(3):176-182

Copyright © 2015 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)