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Indian Journal of Pharmacy and Pharmacology


Study of invitro thrombolytic activity of different extracts of Syzygium cumini


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Research Article

Author Details : Kalyan Ranjan Dash, Jagan Kumar Das*, Amiya Kumar Prusty

Volume : 6, Issue : 3, Year : 2019

Article Page : 79-82


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Abstract

The present study was carried out to investigate the invitro thrombolytic activity of leaf and seed extracts of Syzygium cumini. The thrombolytic activity of different concentration of extracts was compared with the standard drug Streptokinase. The blood collected from human volunteers was taken as test sample for carrying out thrombolytic activity. 800ug/ml leaf extracts of Syzygium cumini showed the mean % of clot lysis as 57.07%+/-0.76, 71.42%+/-0.75 & 86.99%+/-1.33 after incubation for 24hrs, 48hrs, and 72hrs respectively at 37?C. 800ug/ml seed extracts of Syzygium cumini showed the mean % of clot lysis as 44.93%+/-2.49, 66.58%+/-1.41, & 83.32%+/-2.27 after incubation for 24hrs, 48hrs, and 72hrs respectively at 37?C. The mean % clot lysis for the standard drug streptokinase was found to be 75.81% +/-0.71, 88.54%+/-1.02, and 93.04%+/-3.69 after incubation for 24hrs, 48hrs, and 72hrs respectively at 37?C.

Keywords: Aqueous extract, Syzygium cumini, Control, Streptokinase, In-vitro thrombolytic activity.

Doi : 10.18231/j.ijpp.2019.018

How to cite : Dash K R, Das J K, Prusty A K, Study of invitro thrombolytic activity of different extracts of Syzygium cumini. Indian J Pharm Pharmacol 2019;6(3):79-82

Copyright © 2019 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)