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IP Journal of Urology, Nephrology & Hepatology Science


Nephrotoxicity, its mechanism and biomarkers: A systematic review


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Review Article

Author Details : Hemalatha S*, Shivakumar Swamy, Narayan Sha Sonar, Hariprasad M.G, Nandini S

Volume : 2, Issue : 4, Year : 2019

Article Page : 45-49


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Abstract

Nephrotoxicity is a common condition responsible for variety of pathologic conditions on kidney due to the destruction of renal function by one or more nephrotic substance. For renal injury to occur, combination of risk factors (drug, kidney and patient related factors) are generally present. The mechanism involved in nephrotoxicity include altered intraglomerular haemodynamic, crystal nephropathy, inflammation, tubular cell necrosis, throbotic microangiopathy, rabdomyolysis. Nephrotoxicity can be assessed by estimating the blood urea nitrogen (BUN), centralization of serum creatinine, glomerular filtration rate and creatinine clearance. Development of new biomarkers are required for specific diagnosis of nephrotoxicity at earlier stages.

Keywords: Nephrotoxicity, Risk factors, Mechanism, Biomarkers.

How to cite : Hemalatha S, Swamy S, Sonar N S, M.g H, Nandini S, Nephrotoxicity, its mechanism and biomarkers: A systematic review. J Urol Nephrol Hepatol Sci 2019;2(4):45-49

Copyright © 2019 by author(s) and J Urol Nephrol Hepatol Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)