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The Journal of Community Health Management


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Author Details : Abhishek Dixit, Diksha Prakash, Samir Kumar, Mousumi Mutsuddi, OPS Maurya, S P Singh, Abhishek Chand

Volume : 2, Issue : 4, Year : 2015

Article Page : 168-178

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Aim: To investigate the role of the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism in a large cohort of patients with POAG.
Methods: genetic analysis of 80 patients of POAG and 80 controls was done for MTHFR 677C>T polymorphism using PCR.
Results: The C677T genotype is found to be very significantly associated with POAG) as compared to the controls. There is a significant difference in the frequency of distribution of genotype. The homozygous mutant genotype (TT) is also 1.25% more in cases as compared to controls.
Conclusion: There is significant association of MTHFR 677C>T polymorphism with POAG.

Key words:
Glaucoma, Intraocular pressure, Primary open angle glaucoma



How to cite : Dixit A, Prakash D, Kumar S, Mutsuddi M, Maurya O, Singh S P, Chand A, GENETIC ANALYSIS OF PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA (POAG) IN NORTH INDIAN POPULATION. J Community Health Manag 2015;2(4):168-178

Copyright © 2015 by author(s) and J Community Health Manag. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (