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Year 2020

Volume: 5 , Issue: 1

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IP Journal of Diagnostic Pathology and Oncology

Primary neuroendocrine tumors of the gall bladder: Morphology with corroborative immunohistochemistry is the key to diagnosis

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Review Article

Author Details : Mona Bargotya, Ankita Mehta*, Ashish Sachan

Volume : 5, Issue : 1, Year : 2020

Article Page : 1-8

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Neoplasms with neuroendocrine differentiation comprising both neuroendocrine tumors (NETs) and
neuroendocrine carcinomas (NECs) arising in gall bladder are extremely rare. NETs of the gall bladder
represent only 0.2% of all NETs, whereas NECs comprise of 4% cases of all the malignant neoplasms
of the gall bladder. NEC is the most aggressive variant of all gall bladder carcinomas. In most of the
cases diagnosis is incidental and patient usually presents at advanced stage as there are no specific clinical
or radiological features to detect NECs pre-operatively. Histopathology of the resected specimen and
immunochemical analysis remain the main stay of diagnosing these malignancies. This case report includes
3 cases of NECs gall bladder comprising of two cases of small cell NECs and one case of large cell NEC.
Although surgery followed by chemotherapy play important role in improving the quality of life of the
patients, the prognosis of this combative disease can be upgraded by understanding the biological behavior
of these tumours to adapt a definitive treatment protocol. The main aim of this study is to highlight on
the need for better assessment, detection and management of this rare and aggressive entity to improve the
survival rate of the patients of NECs.

Keywords: Neuroendocrine tumor(NET), Neuroendocrine carcinoma(NEC), Immunohistochemistry (IHC), Chemotherapy

Doi : 10.18231/j.jdpo.2020.001

How to cite : Bargotya M, Mehta A, Sachan A, Primary neuroendocrine tumors of the gall bladder: Morphology with corroborative immunohistochemistry is the key to diagnosis. IP J Diagn Pathol Oncol 2020;5(1):1-8

Copyright © 2020 by author(s) and IP J Diagn Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (