COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 165

Article download: 88

Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology

Comparison of serum and salivary enzyme creatine phosphokinase in patients with oral dysplasias

Full Text PDF Share on Facebook Share on Twitter

Research Article

Author Details : Djaynishanth Djanamezeane*, Premraj Prahaspathy

Volume : 5, Issue : 4, Year : 2020

Article Page : 112-118

Suggest article by email


Oral Epithelial Dysplasia (OED) appears as chronic, progressive, premaligant lesions of the oral mucosa, which are considered as the forerunner of Oral cancers, is a threat to the public accounting for increasing number of new cases and deaths worldwide, every year. Most of the oral cancers are detected at a late stage which is difficult to treat as well as has poor prognosis. The application of advanced molecular biological and biochemical methodologies to elucidate the biomarkers of these potentially malignant disorders may help in early detection of these lesions. A precise and more accurate marker which has the potential to predict the progression of a potentially malignant disorder to a malignant state, will enable early diagnosis as well as targeting of these lesions for the subsequent modification of treatment and follow up. One of the important molecular change which accompanies the transformation of a potentially malignant disorder involving the oral cavity to a malignant state is, elevation of serum levels of enzyme, Creatine Phosphokinase, which occurs on account of damage to the connective tissue cells and the deeper submucosal layers due to invasion by the malignant cells. The present study is undertaken to compare the levels of enzyme, Creatine phosphokinase in the serum and saliva of patients with oral dysplastic lesions and henceforth to assess the usefulness of these enzymes as a diagnostic marker of early transformation of these dysplastic lesions to a malignant state.

Keywords: CPK, OED, PMD.

Doi : 10.18231/j.jooo.2019.027

How to cite : Djanamezeane D, Prahaspathy P, Comparison of serum and salivary enzyme creatine phosphokinase in patients with oral dysplasias. J Oral Med Oral Surg Oral Pathol Oral Radiol 2020;5(4):112-118

Copyright © 2020 by author(s) and J Oral Med Oral Surg Oral Pathol Oral Radiol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (