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Journal of Pharmaceutical and Biological Sciences


An efficient synthesis of new benzohydrazide and 1, 3-thiazine fused s-triazines as potential antimicrobial agents


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Author Details : G. M. Malik, T. V. Patel

Volume : 6, Issue : 1, Year : 2018

Article Page : 24-29


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Abstract

As a part of our endeavor toward the synthesis of new heterocyclic bioactive agents, some new substituted 1,3,5 triazine derivatives with 4-nitrobenzohydrazide and 6-(4-methoxyphenyl)-4-phenyl-6H-1,3-thiazin-2-amine and substituted thiourea were reacted and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a micro dilution procedure. Synthesized compounds T1GE to T15GE showed to be effective with MIC (µg/mL), among them T5GE, T8GE, T9GE and T14GE showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1H-NMR, 13C-NMR, MASS Analysis.

Keywords: Cyanuric Chloride, 4-nitrobenzohydrazide, 6-(4-methoxyphenyl)-4-phenyl-6H-1, 3-thiazin-2-amine, Different thiourea derivatives and antimicrobial activity.

Doi : 10.18231/2320-1924.2018.0006

How to cite : Malik G M, Patel T V, An efficient synthesis of new benzohydrazide and 1, 3-thiazine fused s-triazines as potential antimicrobial agents. J Pharm Biol Sci 2018;6(1):24-29

Copyright © 2018 by author(s) and J Pharm Biol Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)