COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article Access statistics

Viewed: 156

Emailed: 0

PDF Downloaded: 73

IP Journal of Surgery and Allied Sciences

Impact of polyethylene glycol plus simethicone on intraluminal bubble score during colonoscopy: A randomized endoscopist blinded trial

Full Text PDF Share on Facebook Share on Twitter

Research Article

Author Details : Vinoth Kumar, Kalaiselvi B, Nandini R, Dutta Trayambak, Ezhil Arasan R*

Volume : 1, Issue : 4, Year : 2019

Article Page : 71-76

Suggest article by email


Introduction and Aim: Colonic air bubbles and foam are major hurdle to a positive colonoscopy. Bubbles hinder mucosal visibility resulting in poor diagnostic precision. This study aimed to determine the efficacy and tolerability of Simethicone in reducing the occurrence of colonic bubbles that could interfere with colon visualization, when added to Polyethylene glycol bowel preparation regimen.
Materials and Methods: This is a prospective randomized observer blind interventional study comparing PEG vs PEG + simethicone. Adult outpatients aged 18 to 60 years undergoing colonoscopy were recruited in this study. The primary outcome was the reduction in bubbles measured by intraluminal bubble score. The secondary outcome measures were patients’ tolerability and endoscopists ease.
Results: The incidence of Score 1 and 2 bubbles was much lower with PEG + simethicone compared with PEG group (P<.0001). Bubble scores in the control vs study group were significantly different in various segments of the colon. Of the 150 Segments of colon caecum, ascending colon, transverse colon, descending colon and rectosimoid examined segments without bubbles in the control vs study group (38.4% vs 88% P<0>
Conclusion: PEG plus simethicone was more effective in reducing bubbles and enhances the mucosal visualization during colonoscopy.

Keywords: Simethicone, Polyethylene glycol, Colonoscopy, Intraluminal bubbles, Bowel preparation.

How to cite : Kumar V, Kalaiselvi B, Nandini R, Trayambak D, Ezhil Arasan R, Impact of polyethylene glycol plus simethicone on intraluminal bubble score during colonoscopy: A randomized endoscopist blinded trial. IP J Surg Allied Sci 2019;1(4):71-76

Copyright © 2019 by author(s) and IP J Surg Allied Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (