COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article Access statistics

Viewed: 170

Emailed: 0

PDF Downloaded: 80

Panacea Journal of Medical Sciences

Solubility enhancement of poorly aqueous soluble novel drug using natural gum as carriers

Full Text PDF Share on Facebook Share on Twitter

Research Article

Author Details : Manoj Kumar Katual*, Gurfateh Singh, S L Harikumar

Volume : 9, Issue : 3, Year : 2019

Article Page : 104-116

Suggest article by email


The current article is based on the concept to enhance the solubility and dissolution rate of a model drug, Rosuvastatin Calcium, which is BCS class-II drug with anti-hyperlipidemic potential. The reported bioavailability from oral route of drug is only 20%. So aim of current study is to improve the solubility and dissolution rate of a poorly water-soluble drug Rosuvastatin Calcium, by solid dispersion technique. Physical mixtures and solid dispersions were prepared using natural polymers A. Marmelos in different to drug to carrier ratios. Prepared formulations were characterized in solid state by FTIR analysis, powder X-ray diffraction, Scanning electron microscopy and in-vitro dissolution study. Solid state characterizations indicated the Rosuvastatin Calcium was present in amorphous form and entrapped in polymer matrix. In contrast to the very slow dissolution rate of pure Rosuvastatin Calcium, the dispersion of the drug in the polymers considerably enhanced the dissolution rate. The mixtures of solid dispersion and excipients were evaluated for pre-compression parameters. After then fast dissolving tablets were prepared by direct compression technique. The formulated tablets were evaluated by post compression parameters. In-vitro drug release performance of the developed formulations was investigated.

Keywords: Solid Dispersion. Natural gums, Anti-lipidemic activity.

Doi : 10.18231/j.pjms.2019.024

How to cite : Katual M K, Singh G, Harikumar S L, Solubility enhancement of poorly aqueous soluble novel drug using natural gum as carriers. Panacea J Med Sci 2019;9(3):104-116

Copyright © 2019 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (