COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Article view: 500

Article download: 269

Panacea Journal of Medical Sciences


Predictors of outcome of cerebral venous sinus thrombosis at a tertiary care centre in Central India


Full Text PDF Share on Facebook Share on Twitter


Author Details : Madhuri Holay, Rajashree Khot, Amit Bhatti, Madhuri Paithankar

Volume : 8, Issue : 1, Year : 2018

Article Page : 3-9


Suggest article by email

Abstract

Cerebral venous sinus thrombosis (CVST) is a less common cause of stroke when compared to arterial thrombosis but its clinical presentation is varied and atypical. Early diagnosis may prevent morbidity & mortality which in untreated cases has been reported as 13.8 -48%.
Materials and Methods: This prospective observational study included 40 radiologically diagnosed cases of CVST, to evaluate the predictors of outcome by using modified Rankin’s Scale (mRS). The primary outcome measure was death or dependency at the end of 12 weeks.
Results: Of 40 patients, 18 cases (45.5%) had mRS 0-3 & 22(55%) had mRS >3. Mean age of the cases was 32.22 yrs with M:F= 1: 0.81. Purperium was the commonest risk factor. In univariate analysis, Age>30(p==0.10), Coma (p=0.010) and Cheyne stokes breathing (p-<0.001) were statistically significant predictors of poor outcome. On CT imaging haemorrhagic infarct & Deep venous sinus thrombosis was a significant predictor of poor outcome (p=<0.001). On multivariate analysis age>30, cerebral haemorrhage and Deep venous sinus thrombosis were the predictors of poor outcome. Rankin’s score of < 2 had good prognosis at 12 weeks follow up. Overall mortality was 15% at 12 weeks follow up.
Conclusion: CVST is an important cause of stroke in puerperium. Neuroimaging plays pivotal role in diagnosis. Modified Rankin’s scale is a simple score system risk stratification of patients with neurodeficit. Low MRS score at hospitalization is associated with better outcome at 12 weeks.

Keywords: Cerebral venous sinus thrombosis (CVST), modified Rankin’s scale (mRS) <2, good outcome.

Doi : 10.18231/2348-7682.2018.0002

How to cite : Holay M, Khot R, Bhatti A, Paithankar M, Predictors of outcome of cerebral venous sinus thrombosis at a tertiary care centre in Central India. Panacea J Med Sci 2018;8(1):3-9

Copyright © 2018 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)