Aim: To compare and evaluate the effect of commercially available products containing CPP-ACP® (GC Tooth mousse, Recaldent; GC corp, Japan), CPP-ACP+ fluoride (GC Tooth Mousse Plus, Recaldent; GC corp, Japan), Novamin (Vantej, Reddy laboratories, India), and NovaMin +fluoride (Sensodyne Repair and Protect, Glaxo Smith Kline, Ontario, USA) on remineralization of enamel as assessed by Enamel micro hardness recovery.
Materials and methods: Enamel slabs obtained from 30 extracted maxillary central incisors were evaluated for baseline micro hardness and then subjected to demineralization. After remineralization cycle using different products, mean and surface changes in micro hardness were measured and compared for different groups.
Results: A statistically significant difference was found between mean values of % micro hardness when compared as Group I v/s II, III, IV and Group II v/s III, IV, and Group III v/s IV (i.e. p<0.01). Novamin+Fluoride performed the best followed by Novamin, CPP-ACP+Fluoride & CPP-ACP.
Conclusion: Novamin based products show superior performance over CPP-ACP based products and that addition of Fluoride to either of these has a synergistic effect on remineralizing potential of these materials.

Keywords: Enamel remineralization, Surface microhardness, Fluoride, Novamin, Casein Phospho-peptide Amorphous Calcium Phosphate (CPP-ACP).